Nonclassical Experimental Design Applied in the Optimization of a Placebo Granulate Formulation in High-Shear Mixer
- 1 January 1996
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 22 (9-10) , 997-1004
- https://doi.org/10.3109/03639049609065931
Abstract
The optimization of wet granulation in a 10-liter high-shear mixer was investigated using a nonclassical experimental mixture design. Hydroxypropylmethylcellulose, lactose, cornstarch, and microcrystalline cellulose were used as excipients of the granulate, while polyvinylpyrrolidone was used as binder. Besides the minimization of the number of experiments, the strategy applied takes into account the cost of each experiment. The introduction of such a modification allowed us to select an experimental matrix giving enough information with a relatively low number of experiments and at a minimum cost.This publication has 5 references indexed in Scilit:
- Experimental Design for a Granulation Process with “Priori” CriteriasDrug Development and Industrial Pharmacy, 1995
- Optimization of Granulates in a High Shear Mixer by Mixture DesignDrug Development and Industrial Pharmacy, 1994
- Simultaneaus Optimization of Several Response Variables in a Granulation ProcessDrug Development and Industrial Pharmacy, 1993
- Non Classical Experimental Designs in Pharmaceutical FormulationDrug Development and Industrial Pharmacy, 1991
- Extreme Vertices Design of Mixture ExperimentsTechnometrics, 1966