Long-Term Synthesis of Antibody in vitro

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Abstract
Organ cultures of rabbit spleen, lymph nodes and thymus, maintained on the surface of agar, retained antibody-producing function for periods of time exceeding those previously reported. The long-term synthetic process requires the presence of normal serum. Such cultures continued to produce antibodies whose synthetic process was initiated in vivo and also manifested clear-cut secondary responses upon stimulation in vitro.