The Clinical Usefulness of ACTH and Cortisone

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Abstract
OVER the past two decades reports on the beneficial effects of adrenocortical extracts in such varied disorders as pemphigus,1 vomiting of pregnancy2 and disturbances of neuromuscular function have appeared.3 Improvement, although often encouraging, was usually transient and difficult to reproduce. The high cost of adrenal extracts and their relatively low potency made it impractical to use pharmacologically effective doses of hormone for prolonged periods. Furthermore, in patients with normal adrenal glands there was the added difficulty of compensating for the suppression of pituitary adrenocorticotrophic hormone (ACTH) production that accompanies the administration of biologically active adrenocortical steroids. These difficulties are best . . .

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