On the substrate specificities of the two forms of monoamine oxidase
- 1 February 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 36 (2) , 111-115
- https://doi.org/10.1111/j.2042-7158.1984.tb03004.x
Abstract
By use of the selective irreversible inhibitors clorgyline and selegiline [(-)-deprenyl], it is possible to determine the Km and Vmax values of the two forms of monoamine oxidase towards a variety of substrates. The validity of this procedure is demonstrated for the deamination of dopamine by rat liver monoamine oxidase -A and -B, and the specificities of the two forms are analysed in terms of their kinetic parameters towards different substrates.This publication has 20 references indexed in Scilit:
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