Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL60 leukemic cells
- 1 March 1992
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 299 (3) , 213-217
- https://doi.org/10.1016/0014-5793(92)80117-y
Abstract
A new property of ursolic acid, lipoxygenase and cyclooxygenase inhibition, has been described in an acetone-extract of heather flowers (Calluna vulgaris) wllich could help explain the anti-inflammatory characteristics of this plant. In mouse peritoneal macrophages, human platelets and differentiated HL60 leukemic cells, ursolic acid, at 1 μM, blocks arachidonate metabolism.Keywords
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