RATES OF PROTEIN SYNTHESIS, AMINO ACID CATABOLISM AND SIZE OF NITROGEN POOL DURING NITROGEN STORAGE INDUCED WITH TESTOSTERONE PROPIONATE, AND TESTOSTERONE PROPIONATE COMBINED WITH GROWTH HORMONE

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Abstract
In the human, normal growth appears to occur in two phases: prepuberal growth, hypothesized as being entirely referable to pituitary growth hormone, and puberal growth referable to steroid growth promoting factors from the gonads and the adrenal cortex (Kinsell et at., 1948). Nitrogen retention and protein anabolic effects of testosterone and its derivatives, methyltestosterone and particularly testosterone propionate have received considerable attention, and, although much factual information has been obtained (Kochakian, 1946, 1950), elucidation of the mechanism of these effects is still awaited. Technical procedures and mathematical treatment developed by Sprinson and’Rittenberg (1949) and Hoberman (1949–50) for assessing protein and amino acid metabolism in terms of rates of protein synthesis, amino acid catabolism, and size of the nitrogen pool have been utilized in characterizing and quantitating the over-all mechanisms involved in nitrogen storage induced in the adult female dog with anterior pituitary growth hormone (Bartlett and Gaebler, 1952).