Extracorporeal Circulation: A Device for the Quantitative Study of Thrombus Formation in Flowing Blood

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Abstract
A standardized extracorporeal shunt system has been described. It allows examination of the sequence of events in thrombus formation and it provides a means of quantitating it in flowing blood. It further allows assessment to be made of the usefulness of classical in vitro clotting tests in thrombogenesis. The platelet adhesive index and clotting time in silicone showed the best correlation with the amount of thrombus formed. Pig serum presumably rich in serum thrombotic accelerator (STA) has been shown to enhance thrombus formation from flowing blood. Within the limits of these experiments, the rate of blood flow has been found to be of little importance.