ENCRUSTATION AND ATHEROSCLEROSIS - ANALOGY BETWEEN EARLY IN VIVO LESIONS AND DEPOSITS WHICH OCCUR IN EXTRACORPOREAL CIRCULATIONS

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  • 1 January 1962
    • journal article
    • research article
    • Vol. 87  (6) , 259-+
Abstract
A study was made of the topography, pattern, and histochemistry of atherosclerosis in man and pigs. The pattern and topography of thrombus formation in models of various vessel configurations coupled into extracorporeal shunts in these animals was investigated as well as the development of atherosclerosis at corresponding sites on swine aortas. The patterns and distribution of deposits found in the models resembled closely those of incipient atherosclerosis at comparable sites in the aortas. The blood platelet was the earliest and most consistent component of the flow chamber deposits. This was demonstrated by microscopy, by radioactive tagging of platelets, and by the use of fluorescent antibodies. The cholesterol and phospholipid content of blood platelets, washed once, was correlated with that in serum. The results of this study suggest that the deposition of platelets may prove to be fundamental mechanism of atherogenesis. This may be influenced by hydraulic factors.