DETERMINATION OF THE LIFE SPAN OF HUMAN BLOOD PLATELETS USING LABELLED DIISOPROPYLFLUOROPHOSPHONATE

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Abstract
A consider-able uptake of DFP32 by the platelets was seen. Results of the determination of platelet-bound radioactivity during several days after the injection of DFP32 showed a linear relationship between time and the platelet-bound radioactivity. This indicates a measurable life span of these elements. The shape of the curves obtained in 5 subjects without hematologic abnormalities suggested that the life span amounts to about 8-9 days. A normal survival time was found in one patient with polycythemia vera and thrombocytosis, one patient with chronic mye-loied leukemia with thrombocytosis and, one patient with persistent thrombocytosis after splenectomy. In two patients with polycythemia vera with low platelet counts a considerable decrease of the life span of the platelets was found. Estimations carried out on two patients during the second week following an operation were not inconsistent with a normal life span of the platelets under these conditions.