Effects of Fluoride on Developing Bones in Tissue Culture
- 1 March 1952
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 79 (3) , 518-520
- https://doi.org/10.3181/00379727-79-19431
Abstract
Isolated metatarsals and fibulas from 10-day-old chick embryos were grown on clotted media containing NaF. Concns. of 1-20,000; 1-10,000; 1-5000 and 1-1000 [image] NaF had no effect on the amt. of calcification. At 1-500 and 1-200 [image] NaF calcification was inhibited. The effect is probably due to interference with the production of phospho-pyruvate as a substrate for bone phosphatase and to some degree of binding of Ca by fluoride.Keywords
This publication has 2 references indexed in Scilit:
- The selective stoppage of bone growth in tissue cultureThe Anatomical Record, 1950
- Calcification of hypertrophic cartilage in vitroBiochemical Journal, 1934