Tolerance to Pituitary-Adrenal Axis Activation by Anticancer Drugs in Normal and Tumour-Bearing Rats

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Abstract
Cisplatinum given intravenously (i.V.), hydroxyurea given orally (os), procarbazine (os) and L-asparaginase (i.V.), on a decreasing scale, produce significant (p< 0.01) adrenocortical activation over 4-h period at a single dose per kg 10 times higher than those employed in human therapy. Only hydroxyurea retained this activity after a 5-day treatment both in normal and Walker carcinosarcoma-bearing rats. Adrenocortical activation depends on the presence of pituitary ACTH both after single or repeated treatments.