Topical Doxorubicin Hydrochloride Therapy for Carcinoma in Situ of the Bladder: A Followup

Abstract
Patients (10) with histologically proved carcinoma in situ of the bladder had remission of tumor after topical chemotherapy with doxorubicin hydrochloride for 24 mo. Of the 10 patients 3 suffered new areas of carcinoma in situ 9-12 mo. after termination of intravesical chemotherapy. Of these 3 patients (1) had a distal ureteral tumor. Fibrosis of the submucosal tissue was observed in every patient but a decrease in bladder capacity was observed in only 1 with prior radiotherapy.