ADJUVANT POLYARTHRITIS .2. SUPPRESSION BY TILORONE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 203  (1) , 156-161
Abstract
Tilorone (5-35 mg/kg per day) suppressed the development of adjuvant-induced arthritis by the injection of Mycobacterium butyricum into rats and the concurrent development of cell-mediated immune response to a secondary immunogen (EL4 cells [mouse lymphoma]) in a dose-related manner. Its influence on the development of the humoral immune response to EL4 cells was found to be dependent on dosage: stimulatory at low doses (7.5 and 11.0 mg/kg per day), but inhibitory at high doses (24.0 and 35.0 mg/kg per day). Single doses of tilorone (30-300 mg/kg), administered at 24 h or l h before the injection of carrageenan, suppressed the development of acute inflammation in the rat. Neither the anti-inflammatory effect of tilorone, nor its influence on the immune response, could account for its antiarthritic effect. The compound may act via interferon induction.