Urethane (Ethyl Carbamate) Therapy in Spontaneous Leukemias in Mice

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Abstract
Definite palliative effects of daily sub-anesthetic doses of urethane were observed in 18 cases of spontaneous leukemia in mice. The effects were: a pronounced fall in total white-cell count to or below normal limits and a maintenance of these levels with continued therapy; a marked reduction in the number of immature cells in the circulating blood; a possible stabilizing effect on the Hb levels; and a pronounced diminution in the size of enlarged lymph nodes and spleen. The life expectancy also is indicated. In 8 leukemic mice with initial thymic involvement, the same effects were obtained. In addition, there was relief from symptoms of dyspnea and thoracic enlargement, a decrease in the size of the thymus, and a statistically significant lengthening of life.