Monoclonal Anti‐B as a New Blood‐Typing Reagent

1 February 1981

journal article
research article
Published by Wiley in Vox Sanguinis

Vol. 40 (2) , 99-104
https://doi.org/10.1111/j.1423-0410.1981.tb00677.x

Abstract

Stable cloned lines of anti‐B‐secreting cells have been derived by fusing spleen cells of a mouse immunized by group B antigen with a mouse myeloma line. The tissue culture supernatant of one of them (NBI/19.112.28) containing secreted monoclonal anti‐B antibody is an especially good blood‐grouping reagent, well suited for use with manual and automated methods. The unlimited availability of a potent reagent of uniform properties, cheaply produced by a single source, makes monoclonal anti‐B a serious competitor to human typing serum.

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