Pharmacokinetics and pharmacodynamics of methylprednisolone when administered at 8 AM versus 4 PM
- 1 June 1992
- journal article
- clinical trial
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 51 (6) , 677-688
- https://doi.org/10.1038/clpt.1992.80
Abstract
The temporal variations in the pharmacokinetics and pharmacodynamics of methylprednisolone at 8 AM versus 4 PM were investigated in six healthy male volunteers. Subjects completed three phases: no dr...Keywords
This publication has 42 references indexed in Scilit:
- Two-compartment basophil cell trafficking model for methylprednisolone pharmacodynamicsJournal of Pharmacokinetics and Biopharmaceutics, 1991
- Steroid dose sparing: Pharmacodynamic responses to single versus divided doses of methylprednisolone in manJournal of Allergy and Clinical Immunology, 1990
- Chronopharmacokinetic and bioequivalence studies of two formulations of trimipramine after oral administration in manEuropean Journal of Drug Metabolism and Pharmacokinetics, 1989
- Two populations of human blood basophils: Effect of prednisone on circulating numbersJournal of Allergy and Clinical Immunology, 1987
- Corticosteroid effects on circulating lymphocyte subset levels in normal humansJournal of Clinical Immunology, 1984
- Circadian variation of lymphocyte subpopulations: a study with monoclonal antibodies.BMJ, 1983
- Circadian changes in effectiveness of corticosteroids in eight patients with allergic asthmaJournal of Allergy and Clinical Immunology, 1983
- Time of day of prednisolone administration in rheumatoid arthritis.Annals of the Rheumatic Diseases, 1982
- Possible effect of time on renal allograft rejection.BMJ, 1979
- THEOPHYLLINE PHARMACOKINETICS AND RESPIRATORY INFECTIONSThe Lancet, 1978