Tetrocarcins E1,E2,F and F-1, new antibiotics. Fermentation, isolation and characterization.
- 1 January 1982
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 35 (8) , 979-984
- https://doi.org/10.7164/antibiotics.35.979
Abstract
New components of tetrocarcins (E1, E2, F and F-1) were found in the culture broth of Micromonospora chalcea KY 11091 that was known to produce tetrocarcins A, B and C. Tetrocarcin F-1 consisted of tetronolide and nitro sugar (tetronitrose). Tetrocarcins E1 and E2 consisted of F-1 and deoxy sugar (L-digitoxose). Tetrocarcin F consisted of F-1 and 2 deoxy sugars (their structures have not yet been determined). They all showed antibacterial activities against gram-positive bacteria, and the specific activity decreased with a decrease in the numbers of deoxy sugars attached to the aglycone.This publication has 2 references indexed in Scilit:
- Tetrocarcins, novel antitumor antibiotics. I. Producing organism, fermentation and antimicrobial activity.The Journal of Antibiotics, 1980
- Tetrocarcins, novel antitumor antibiotics. II. Isolation, characterization and antitumor activity.The Journal of Antibiotics, 1980