Role of Dietary Factors in the Hyperinsulinemia of Genetically Obese Hyperglycemic (ob/ob) Mice

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Abstract
To investigate the role of different macronutrients in the hyperinsulinemia of genetically obese hyperglycemic (ob/ob) mice, we examined the insulin response of fasted adult ob/ob mice to the voluntary ingestion of foods with different protein, fat and carbohydrate compositions. During a 3-hour period after ingestion, there was a marked association between the extent of the insulin response and the rise in plasma glucose concentrations. The data suggest that dietary carbohydrate is the nutrient predominantly responsible for the severity of the hyperinsulinemia in adult ob/ob mice. The pronounced insulin-releasing effect of dietary carbohydrate in these mice cannot be attributed to a direct action of glucose on the pancreatic B cells. Thus, the results indicate an important role of the enteroinsular axis in the genesis of the marked insulin-releasing effect of dietary carbohydrate in adult ob/ob mice.