Theoretical treatment of microtubules disappearing in solution.
- 1 June 1985
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 82 (12) , 4127-4131
- https://doi.org/10.1073/pnas.82.12.4127
Abstract
The origin of the 2-phase (cap, no cap) macroscopic kinetic model of the end of a microtubule is reviewed. The model is then applied to a new theoretical problem, namely, the Mitchison-Kirschner experiment in which aggregated microtubules in solution spontaneously decrease in number (shorten to disappearance) while the surviving microtubules increase in length. The model fits the experiments without difficulty.This publication has 12 references indexed in Scilit:
- Monte Carlo study of the GTP cap in a five-start helix model of a microtubule.Proceedings of the National Academy of Sciences, 1985
- Introductory analysis of the GTP-cap phase-change kinetics at the end of a microtubule.Proceedings of the National Academy of Sciences, 1984
- Microtubule assembly nucleated by isolated centrosomesNature, 1984
- Dynamic instability of microtubule growthNature, 1984
- Phase changes at the end of a microtubule with a GTP cap.Proceedings of the National Academy of Sciences, 1984
- Interference of GTP hydrolysis in the mechanism of microtubule assembly: an experimental study.Proceedings of the National Academy of Sciences, 1984
- Steady-state theory of the interference of GTP hydrolysis in the mechanism of microtubule assembly.Proceedings of the National Academy of Sciences, 1983
- Bioenergetics and Kinetics of Microtubule and Actin Filament Assembly–DisassemblyPublished by Elsevier ,1982
- Kinetic analysis of guanosine 5'-triphosphate hydrolysis associated with tubulin polymerizationBiochemistry, 1981
- Head to tail polymerization of actinJournal of Molecular Biology, 1976