A Highly Regio- and Stereoselective Carbocupration of Fluoroalkylated Internal Alkynes: A Short Total Synthesis of the Antiestrogenic Drug Panomifene
- 24 February 2004
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (6) , 933-936
- https://doi.org/10.1021/ol036440n
Abstract
[reaction: see text] A highly regio- and stereoselective carbometalation reaction of fluoroalkylated internal alkynes with organocopper reagents is described. This reaction is utilized successfully in the short, stereoselective total synthesis of the antiestrogenic drug panomifene.Keywords
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