Synthesis of the (E) and (Z) isomers of the antiestrogen tamoxifen and its metabolite, hydroxytamoxifen, in tritium-labeled form
- 1 June 1982
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 47 (12) , 2387-2393
- https://doi.org/10.1021/jo00133a030
Abstract
No abstract availableThis publication has 12 references indexed in Scilit:
- Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues.Journal of Biological Chemistry, 1981
- Biological Potency and Uterine Estrogen Receptor Interactions of the Metabolites of the Antiestrogens CI628 and U23,469*Endocrinology, 1981
- Estrogen receptor-based imaging agents. 1. Synthesis and receptor binding affinity of some aromatic and D-ring halogenated estrogensJournal of Medicinal Chemistry, 1980
- Comparison of tamoxifen and hypophysectomy in breast cancer treatmentCancer, 1980
- Evaluation of the antitumour activity of the non-steroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma modelPublished by Elsevier ,1980
- TAMOXIFEN AND FLUOXYMESTERONE IN ADVANCED BREAST-CANCER - A CONTROLLED CLINICAL-TRIAL1980
- Antiestrogens and antiestrogen metabolites: preparation of tritium-labeled (.+-.)-cis-3-[p-(1,2,3,4-tetrahydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy]-1,2-propanediol and characterization and synthesis of a biologically important metaboliteJournal of Medicinal Chemistry, 1979
- A MONOHYDROXYLATED METABOLITE OF TAMOXIFEN WITH POTENT ANTIOESTROGENIC ACTIVITYJournal of Endocrinology, 1977
- Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinomataPublished by Elsevier ,1976
- A NON-STEROIDAL ESTROGEN ANTAGONIST l-(p-2-DIETHYLAMINOETHOXYPHENYLH-PHENYL-2-p-METHOXYPHENYL ETHANOLEndocrinology, 1958