lodothyronine Release from the Perfused Canine Thyroid

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Abstract
The pattern of thyroid secretion was examined more closely than can be done by measuring iodothyronines in peripheral blood. A thyroid perfusion model was developed from 2 separate thyroid lobes of dogs. T4 [thyroxine] T3 [triiodothyronine] and rT3 [reverse triiodothyronine] were measured in thyroid effluent and hydrolysate by radioimmunoassays. TSH [thyrotropin] infusion was accompanied by an increase in iodothyronine release after a certain lag period. The length of this period varied inversely with the concentration of TSH in the perfusion medium. High concentrations of TSH and cyclic AMP induced very similar patterns of secretion.