Thyroidal and Peripheral Production of Thyroid Hormones
- 1 December 1977
- journal article
- review article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 87 (6) , 760-768
- https://doi.org/10.7326/0003-4819-87-6-760
Abstract
There are 2 biologically active thyroid hormones, thyroxine (T4) and triiodothyronine (T3). Most T3 is produced extrathyroidally, so that alterations in circulating thyroid hormone concentrations may occur as a result of both thyroidal and extrathyroidal abnormalities. Extrathyroidal T4 conversion to T3 is decreased in patients with different acute and chronic illnesses. When T4 conversion to T3 is impaired and serum T3 concentrations decline, serum concentrations of biologically inactive 3,3'',5''-triiodothyronine (reverse T3) increase. Current information is reviewed on thyroidal and extrathyroidal T4 and T3 production in normal subjects and patients with various thyroid diseases and other illnesses. The physiologic significance of these changes, and the value and interpretation of various iodothyronine measurements are discussed.Keywords
This publication has 24 references indexed in Scilit:
- Thyroid Function and Metabolic State in Chronic Renal FailureAnnals of Internal Medicine, 1976
- Factors Influencing the Concentration of Free and Total Thyroxine in Patients with Nonthyroidal DiseaseJournal of Clinical Endocrinology & Metabolism, 1966
- Preparation of I-131-labeled human serum prealbumin and its metabolism in normal and sick patients.Journal of Clinical Investigation, 1965
- Whole-Body Counting of131I-Labeled ThyroxineJournal of Clinical Endocrinology & Metabolism, 1964
- BINDING OF THYROXINE BY SERUM PROTEINS EVALUATED BY EQUILIBRIUM DIALYSIS AND ELECTROPHORETIC TECHNIQUES. ALTERATIONS IN NON-THYROIDAL ILLNESS*Journal of Clinical Investigation, 1963
- Biological Activity of 3,3′,5′-Triiodo-DL-ThyronineEndocrinology, 1962
- ANTIGOITROGENIC AND CALORIGENIC ACTIVITIES OF THYROXINE ANALOGUES IN RATS1Endocrinology, 1959
- THEIN VIVOCONVERSION OF THYROXINE TO 3:5:3′-TRIIODOTHYRONINEJournal of Clinical Endocrinology & Metabolism, 1958
- Simultaneous Estimation of Rates of Thyroxine Degradation and Thyroid Hormone Synthesis1Journal of Clinical Investigation, 1955
- Quantitative Aspects of Iodine Metabolism. The Exchangeable Organic Iodine Pool, and the Rates of Thyroidal Secretion, Peripheral Degradation and Fecal Excretion of Endogenously Synthesized Organically Bound IodineJournal of Clinical Investigation, 1954