High potency dipeptide sweeteners. 1. L-Aspartyl-D-phenylglycine esters
- 1 March 1990
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 33 (3) , 1052-1061
- https://doi.org/10.1021/jm00165a027
Abstract
Twenty esters of L-aspartyl-D-phenylglycine, as well as two substituted analogues, an o-fluoro and a p-hydroxyphenylglycine ester, were prepared. The L-aspartyl-D-phenylglycine (-)-.alpha.- and (+)-.beta.-fenchyl esters had the highest sweetness potency at 1200 and 3700 times that of sucrose, respectively. The high potency of these sweeteners is surprising as the phenyl group occupies a position previously believed to accommodate only much smaller groups.This publication has 8 references indexed in Scilit:
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