False-Positive Rate of a “Fourth-Generation” HIV Antigen/Antibody Combination Assay in an Area of Low HIV Prevalence
- 1 October 2010
- journal article
- research article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 17 (10) , 1642-1644
- https://doi.org/10.1128/cvi.00258-10
Abstract
We retrospectively analyzed the performance of the Architect HIV antigen/antibody (Ag/Ab) combination assay in a tertiary health care center with a situation of low HIV prevalence. The specificity and positive predictive value (PPV) were 99.78% and 31.21%, respectively. However, the specificity and PPV could increase to 99.99% and 89.70% using an arbitrary cutoff value.Keywords
This publication has 12 references indexed in Scilit:
- A Human Immunodeficiency Virus Screening Algorithm to Address the High Rate of False-Positive Results in Pregnant Women in JapanPLOS ONE, 2010
- HIV Screening and False-Positive ResultsHIV Screening and False-Positive ResultsJAMA, 2007
- HIV Screening and False-Positive ResultsHIV Screening and False-Positive ResultsPublished by American Medical Association (AMA) ,2007
- Faculty Opinions recommendation of Revised recommendations for HIV testing of adults, adolescents, and pregnant women in health-care settings.Published by H1 Connect ,2006
- Screening of HIV infection: role of molecular and immunological assaysExpert Review of Molecular Diagnostics, 2006
- Home Testing for HIVNew England Journal of Medicine, 2006
- Guidelines for laboratory testing and result reporting of antibody to hepatitis C virus. Centers for Disease Control and Prevention.2003
- Multicenter Evaluation of a New Automated Fourth-Generation Human Immunodeficiency Virus Screening Assay with a Sensitive Antigen Detection Module and High SpecificityJournal of Clinical Microbiology, 2002
- Evaluation of a New Combined Antigen and Antibody Human Immunodeficiency Virus Screening Assay, VIDAS HIV DUO UltraJournal of Clinical Microbiology, 2002
- Reduction of Diagnostic Window by New Fourth-Generation Human Immunodeficiency Virus Screening AssaysJournal of Clinical Microbiology, 1998