Sequential mono-N-arylation of piperazine nitrogens. Part 1: A simplified method and its application to the preparation of a key N,N′-biaryl piperazine antifungal intermediate
- 30 July 1999
- journal article
- Published by Elsevier in Tetrahedron Letters
- Vol. 40 (31) , 5655-5659
- https://doi.org/10.1016/s0040-4039(99)01103-x
Abstract
No abstract availableKeywords
This publication has 22 references indexed in Scilit:
- Pd-catalyzed aminations of aryl triazolones: Effective synthesis of hydroxyitraconazole enantiomersTetrahedron Letters, 1998
- Design and Synthesis of an orally active GPIIb/IIIa antagonist based on a phenylpiperazine scaffoldBioorganic & Medicinal Chemistry Letters, 1998
- Arylpiperazines with Serotonin-3 Antagonist Activity: A Comparative Molecular Field AnalysisJournal of Medicinal Chemistry, 1998
- Rapid and efficient synthesis of 1-arylpiperazines under microwave irradiationTetrahedron Letters, 1997
- The synthesis and evaluation of the major metabolites of mazapertineBioorganic & Medicinal Chemistry Letters, 1997
- New 2-Piperazinylbenzimidazole Derivatives as 5-HT3Antagonists. Synthesis and Pharmacological EvaluationJournal of Medicinal Chemistry, 1997
- Concise asymmetric routes to 2,2,4-trisubstituted tetrahydrofurans via chiral titanium imide enolates: Key intermediates towards synthesis of highly active azole antifungals SCH 51048 and SCH 56592Tetrahedron Letters, 1996
- Substituted 1,3,5-triazines as cholesteryl ester transfer protein inhibitorsBioorganic & Medicinal Chemistry Letters, 1996
- Synthesis and serotonergic activity of arylpiperazide derivatives of serotonin: potent agonists for 5-HT1D receptorsJournal of Medicinal Chemistry, 1995
- Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-onesJournal of Medicinal Chemistry, 1984