Impact of Hepatitis C Virus (HCV) Genotypes on Quantification of HCV RNA in Serum by COBAS AmpliPrep/COBAS TaqMan HCV Test, Abbott Antiretroviral Therapy HCV RealTime Assay, and VERSANT HCV RNA Assay
- 1 September 2007
- journal article
- research article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 45 (9) , 3077-3081
- https://doi.org/10.1128/jcm.00111-07
Abstract
The VERSANT HCV RNA 3.0 (bDNA), COBAS AmpliPrep/COBAS TaqMan HCV, and Abbott ART HCV RealTime assays were compared for hepatitis C virus RNA quantification in 158 clinical specimens (genotypes 1 to 5). RNA values differed significantly between methods ( P < 0.0001), and mean titer differences ranged from 0.01 to 0.50 log 10 IU/ml depending on the genotypes.Keywords
This publication has 17 references indexed in Scilit:
- Multilaboratory Comparison of Hepatitis C Virus Viral Load AssaysJournal of Clinical Microbiology, 2006
- Comparison of Conventional PCR with Real-Time PCR and Branched DNA-Based Assays for Hepatitis C Virus RNA Quantification and Clinical Significance for Genotypes 1 to 5Journal of Clinical Microbiology, 2006
- HCV virological assessmentJournal of Hepatology, 2005
- Consensus Proposals for a Unified System of Nomenclature of Hepatitis C Virus Genotypes *Hepatology, 2005
- Peginterferon-α-2a (40KD) and Ribavirin for 16 or 24 Weeks in Patients With Genotype 2 or 3 Chronic Hepatitis CGastroenterology, 2005
- Clinical utility of viral load measurements in individuals with chronic hepatitis C infection on antiviral therapyJournal of Viral Hepatitis, 2005
- Assessment of early virological response to antiviral therapy by comparing four assays for HCV RNA quantitation using the international unit standard: Implications for clinical management of patients with chronic hepatitis C virus infectionJournal of Medical Virology, 2005
- New approaches and therapeutic modalities for the prevention and treatment of recurrent HCV after liver transplantationLiver Transplantation, 2003
- New approaches and therapeutic modalities for the prevention and treatment of recurrent HCV after liver transplantationLiver Transplantation, 2003
- STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENTThe Lancet, 1986