A Cytotoxic Melanin Precursor, 5,6-Dihydroxyindole, from the Folkloric Anti-Cancer PlantRhaphidophora Korthalsii
- 1 December 1996
- journal article
- research article
- Published by Taylor & Francis in Natural Product Letters
- Vol. 9 (2) , 137-140
- https://doi.org/10.1080/10575639608044937
Abstract
5,6-Dihydroxyindole (1a) was isolated by bioactivity-directed fractionation from fresh leaves of Rhaphidophora korthalsii. The unstable compound and its stable diacetate (1b) were characterized spectroscopically and confirmed by synthesis. The ED50 of 1a against P388 cells was 3.5 μg/ml.Keywords
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