Reciprocal translocation between chromosomes 8 and 9 in atypical chronic myeloid leukaemia.
Open Access
- 1 October 1985
- journal article
- case report
- Published by BMJ in Journal of Medical Genetics
- Vol. 22 (5) , 398-401
- https://doi.org/10.1136/jmg.22.5.398
Abstract
A balanced translocation t(8;9) (p11;q34) was present in the peripheral blood, bone marrow, and spleen cells of a patient with Ph negative chronic myeloid leukaemia. Subsequent transformation into acute leukaemia was associated with the emergence of trisomy 8 and der(8)(8qter----cen----8p11::9q34----9qter). This is the third reported case of t(8;9) (p11;q34) and raises the question of the role of c-abl in the pathogenesis of this myeloproliferative disorder.Keywords
This publication has 17 references indexed in Scilit:
- Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemiaNature, 1983
- Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemiaNature, 1983
- Novel reciprocal translocation between chromosomes 8 and 9 found in a patient with myeloproliferative disorderCancer Genetics and Cytogenetics, 1983
- Chromosome Abnormalities in Malignant Hematologic DiseasesPublished by Elsevier ,1982
- Unusual translocation and chronic myelocytic leukemia: “masked” Philadelphia chromosome (Ph1)Cancer Genetics and Cytogenetics, 1981
- Chromosomes and causation of human cancer and leukemia: XL. The Ph1 and other translocations in CMLCancer, 1980
- Y-Chromosome Structural Rearrangement in Philadelphia Chromosome-Negative Chronic Myelogenous LeukemiaNew England Journal of Medicine, 1980
- Chronic Granulocytic LeukemiaMedical Clinics of North America, 1976
- A 9/11 translocation in a child with Ph1-negative chronic myelogenous leukemiaThe Journal of Pediatrics, 1976
- A RAPID BANDING TECHNIQUE FOR HUMAN CHROMOSOMESThe Lancet, 1971