Sites and Mechanisms of Action of Halothane on Skeletal Muscle Function in Vitro

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Abstract
In isolated rat diaphragm strips, halothane augments the tension produced during caffeine-induced contractures in a dose-related manner. K-induced contracture tension was augmented in the presence of halothane to a concentration of 0.75%, and decreased at halothane concentrations of more than 1%. The time to peak tension for K-induced contractures was diminished by all halothane concentrations. T-tubular disruption by hypertonic glycerol does not alter anesthetic-induced augmentation of caffeine-induced contractures. Halothane may augment C-release processes in sarcoplasmic reticulum. Membrane events or excitation-contraction coupling steps may be also altered by halothane.

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