1-Hydrazinophthalazine (Apresoline in the) reatment of Hypertension: A Two Year Study

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Abstract
Patients with severe essential hypertension have been carefully studied periodically in an attempt to group them as to probable life expectancy. Forty such patients have been observed while on oral 1-hydrazinophthalazine and a low salt diet. Nineteen of the 33 patients in the groups having a relatively good prognosis for survival had some decrease in diastolic pressure. Only one of seven patients in Smithwick group IV had a satisfactory reduction in blood pressure.