Adverse Effect of Cyclophosphamide at Moderate Dose in Combination with Standard Drugs on Intraperitoneally Implanted Lewis Lung Carcinoma in Mice
- 1 January 1985
- journal article
- research article
- Published by S. Karger AG in Chemotherapy
- Vol. 31 (3) , 216-222
- https://doi.org/10.1159/000238339
Abstract
Adverse (tumor-enhancing) effects of cyclophosphamide at moderate dose (50 mg/kg) given therapeutically were confirmed on the intraperitoneally implanted Lewis lung carcinoma (LLC) in allogeneic DBA/2 and BALB/c mice. It was recently demonstrated that antitumor effects of five standard drugs (actinomycin D, adriamycin, BCNU, 5-fluorouracil and methotrexate) were abolished or diminished when cyclophosphamide (50 mg/kg) was therapeutically combined with such drugs against intraperitoneally implanted LLC both in syngeneic C56BL/6 and allogeneic DBA/2 and BALB/c mice, while the effects of three drugs (cis-diamminedichloroplatinum, 5-thio-guanine and vincristine) were not affected by the cyclophosphamide therapy. It is suggested that cyclophosphamide therapy at adjusted lower doses in man might not only be effective but also have a risk to enhance tumor growth and diminish the beneficial effects of other drugs in combination chemotherapy.This publication has 11 references indexed in Scilit:
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