Gonadotropin Excretion in Normal Men and Women and Cases of Hysterectomy, Menopause, Migraine, Epilepsy and Eunuchoidism

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Abstract
Gonadotrophin was '' concentrated from entire 1st morning specimen of urine, by the alc. precipitation method. Toxic salts were removed by dialysis or by several washings with 80% alc. The entire amt. was injected in one 21 day old rat, in 9 injs. The uterine wt. was used as an index, unless over 150 mg., when ovarian wts. were also recorded. A normal young showed a single peak of urinary gonadotrophin between menses, and another showed 2 peaks. A hysterectomized had normal single and double peaks in corresponding periods. A young with premature menopause showed a constant high urinary titer, which was reduced in proportion to the dosage of estrogen, suggesting a means of estrogen assay in the human. A normal [male] had no appreciable secretion; 1 with migraine showed high and irregular excretion which disappeared with successful dietary treatment. One epileptic had a high excretion but 2 others had none. A eunuchoid [male] showed no excretion.

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