Molecular Mechanisms of Radiation Oncogenesis
- 1 January 1994
- journal article
- review article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 65 (1) , 57-64
- https://doi.org/10.1080/09553009414550081
Abstract
Resolving the molecular mechanisms of radiation oncogenesis represents an important but daunting challenge in radiation research. This brief review outlines the principal oncogenic mechanisms that need to be considered in the context of radiation effects on the genome, how these might relate to specific gene and chromosomal changes relevant to neoplasia and the possible implications of such knowledge for the modelling of cancer risk. The long-term application of this mechanistic knowledge to the determination of tumour causality and for the assessment of individual cancer risk is also briefly discussed.Keywords
This publication has 44 references indexed in Scilit:
- A death in the life of p53Nature, 1993
- Breast cancer genes: how many, where and who are they?Nature Genetics, 1992
- p53, guardian of the genomeNature, 1992
- Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC GeneScience, 1992
- Predisposition to Renal Cell Carcinoma Due to Alteration of a Cancer Susceptibility GeneScience, 1992
- Inherited predisposition to cancerTrends in Genetics, 1990
- Genomic imprinting and genetic disorders in manTrends in Genetics, 1989
- ras GENESAnnual Review of Biochemistry, 1987
- Breast and Other Cancers in Families with Ataxia-TelangiectasiaNew England Journal of Medicine, 1987
- The nature of mutants induced by ionising radiation in cultured hamster cells III. Molecular characterization of HPRT-deficient mutants induced by γ-rays or α-particles showing that the majority have deletions of all or part of the hprt geneMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1986