The Action of Aureomycin and other Chemotherapeutic Agents in Experimental Brucellosis

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Abstract
Summary and Conclusions: A method is described for testing the action of drugs against the acute lethal effect of brucella in mice. Of the agents believed to be therapeutically effective in human brucellosis, aureomycin and a combination of streptomycin and sulfadiazine afforded mice excellent protection against the acute lethal effect of brucella. When chloramphenicol was given in the largest doses possible to administer by injection, there was only slight protection. Mice were protected against the acute lethal effect of brucella as late as 72 hours and possibly 96 hours after the last dose of aureomycin. The protective action of aureomycin against the acute lethal effect of brucella may be due to a primary antitoxic property. Aureomycin inhibited the multiplication of Brucella abortus in sublethal infections of mice and Br. suis in sublethal infections of guinea pigs. In a small minority of animals infected with Br. abortus, there was evidence that the infection was prevented after treatment with aureomycin. The action of aureomycin in experimental brucellosis has been compared with its action in brucellosis in man.