Effect of Erythroid Hyperplasia on the Disappearance Rate of Erythropoietin in the Dog

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Abstract
The disappearance rate of erythropoietin was measured in dogs with normal or hyperplastic marrow. Erythroid hyperplasia was achieved by bleedings or phenylhydrazine. Erythropoietin plasma titer was increased by Co administration, and 12 hr. later, bilateral nephrectomy was performed to suppress erythropoietin production. The hormone plasma level was measured during the next 7 hr. Erythropoietin T/2 averaged 6.0 hr. in dogs with normal marrow, 6.5 and 6.3 hr. respectively in dogs with bleeding or phenylhydrazine induced hyperplasia. These results do not support the hypothesis that erythropoietin utilization is related to the erythroid marrow activity.