Leukocyte trafficking in free‐flowing cerebrospinal fluid of normal rhesus macaques (Macaca mulatta)
- 1 January 1996
- journal article
- Published by Wiley in Journal of Medical Primatology
- Vol. 25 (1) , 8-13
- https://doi.org/10.1111/j.1600-0684.1996.tb00186.x
Abstract
Cellular components in free-flowing cerebrospinal fluid (CSF) of normal rhesus macaques were characterized. Microscopic counting enumerated the total number of leukocytes, percentage of polymorphonuclear cells (PMN), leukocytes with nonspecific esterase (NSE), and those reducing nitro blue tetrazolium (NBT). Flow cytometric analysis further identified CD4, CD8, CD14, and CD20 positive leukocytes. These experiments established reliable techniques for evaluating cellular components in CSF from rhesus macaques and documented the difference in the CD4/CD8 ratio between peripheral blood (PB) and CSF compartments under normal physiological conditions.Keywords
This publication has 16 references indexed in Scilit:
- In healthy primates, circulating autoreactive T cells mediate autoimmune disease.Journal of Clinical Investigation, 1994
- Early activation of PBMC and appearance of antiviral CD8+ cells influence the prognosis of SIV‐induced disease in rhesus macaquesJournal of Medical Primatology, 1994
- Characterization of T and B Cells Isolated from Mucosa-Associated Tissues of the Rhesus MacaqueCellular Immunology, 1993
- Adhesion molecule expression on cerebrospinal fluid T lymphocytes: Evidence for common recruitment mechanisms in multiple sclerosis, aseptic meningitis, and normal controlsAnnals of Neurology, 1993
- Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversityPublished by Elsevier ,1991
- Flow cytometric methods for RNA content analysisMethods, 1991
- T‐lymphocyte entry into the central nervous systemJournal of Neuroscience Research, 1991
- Spontaneous NBT reduction by monocytes as a marker of disease activity in children with histiocytosisBritish Journal of Haematology, 1990
- Spontaneous NBT reduction by monocytes as a marker of disease activity in children with histiocytosisBritish Journal of Haematology, 1990
- Fluctuations of T- and B-cell subsets in basic protein-induced experimental allergic encephalomyelitis (EAE) in long-tailed macaquesClinical Immunology and Immunopathology, 1987