Bacillus anthracisEdema Toxin InhibitsStaphylococcus aureusEnterotoxin B Effects In Vitro: a Potential Protein Therapeutic?
- 1 October 2005
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 73 (10) , 7069-73
- https://doi.org/10.1128/iai.73.10.7069-7073.2005
Abstract
Various in vitro effects of staphylococcal enterotoxin B (SEB) on human peripheral blood mononuclear cells were mitigated byBacillus anthracisedema toxin. In particular, levels of some SEB-induced cytokines (tumor necrosis factor alpha, gamma interferon) and chemokines (monocyte chemoattractant protein 1, macrophage inflammatory protein 1 alpha [MIP-1α], MIP-1β) were significantly diminished or even nonexistent, depending upon the timing of edema toxin administration. Overall, these results suggest a novel use ofB. anthracisedema toxin against a bacterial superantigen.Keywords
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