Effects of Ethionine and Methionine on Serum Lipids and Lipoproteins

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Abstract
Prolonged feeding of ethionine to rats receiving a diet containing cholesterol, cholic acid and hydrogenated coconut oil leads to about a 10-fold rise in serum triglyceride concentration which is primarily confined to triglycerides bound to low-density lipoproteins. This increase is prevented if an equal amount of methionine is included in the diet. Serum cholesterol concentrations of rats fed ethionine are lower than those of unsupplemented rats. Addition of methionine with ethionine further lowers the cholesterol concentration. Methionine lowers the concentrations of serum triglycerides and phospholipids only slightly but substantially lowers serum cholesterol concentration.