Salt-Losing Nephritis

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Abstract
THE phenomenon of excessive loss of salt in the urine of patients with chronic Bright's disease has been known for many years. Peters and his coworkers,1 in 1929, described patients with renal disease who had excessive excretion of chloride in the urine in spite of markedly decreased serum chloride concentrations. By giving large amounts of salt, they found it possible to maintain serum chloride at normal values. They suggested that in some cases of nephritis salt deprivation was dangerous and, indeed, recommended supplemental sodium chloride to prevent salt depletion.In 1944 Thorn, Koepf and Clinton2 first reported the clinical implications . . .