PHOSPHONOLIPIDS: VIII. SYNTHESIS OF PHOSPHONIC ACID ANALOGUES OF DIETHERL-α-LECITHINS
- 1 February 1967
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 45 (2) , 317-325
- https://doi.org/10.1139/o67-035
Abstract
A method is described that permits the synthesis of the racemic as well as both enantiomeric forms of phosphonic acid analogues of saturated or unsaturated diether α-lecithins.The phosphonic acid analogues of diether α-lecithins are obtained by phosphonylating saturated or unsaturated D-, L-, or DL-α,β-di-O-alkyl glycerol ethers with 2-bromoethylphosphonic acid monochloride in the presence of triethylamine at 0–5°, and treating the resulting di-O-alkyi α-glyceryl-(2-bromoethyl)phosphonates with trimethylamine in dimethylformamide at 50–55°.This publication has 19 references indexed in Scilit:
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