Low Fasting Plasma Glucose Level as a Predictor of Cardiovascular Disease and All-Cause Mortality

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Abstract
Background —Although medical textbooks usually classify fasting plasma glucose Methods and Results —We conducted prospective cohort studies among 40 069 men and women to investigate the association between fasting plasma glucose levels and cardiovascular disease and all-cause mortality. We documented a U-shaped relation between fasting plasma glucose and mortality. In addition to diabetes and impaired fasting glucose levels, low fasting plasma glucose levels were also associated with high mortality. After multivariate adjustment for age, sex, study population, ethnicity, current smoking status, high blood pressure, total cholesterol, body mass index, triglycerides, history of cardiovascular disease and cancer, and a family history of cardiovascular disease, patients with fasting plasma glucose P P Conclusions —Participants with low fasting plasma glucose levels had a high risk of cardiovascular disease and all-cause mortality.