Effects of Octachloronaphthalene on Vitamin A Metabolism in the Rat

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Abstract
The addition of 0.05 to 0.30% of octachloronapthalene to the diet of rats greatly accelerated the loss of vitamin A from the liver. There was no effect on the vitamin A or vitamin E in the blood, nor did the vitamin E in the liver change significantly. Utilization of injected carotene was not impaired by feeding octachloronaphthalene but a marked decrease in utilization occurred with carotene given per os. Octachloronaphthalene in the diet caused the excretion in the feces of an unidentified yellow material. The addition of 8% of brewers' yeast to a purified diet containing octachloronaphthalene prevented fatty infiltration in the liver, but did not eliminate the accompanying hypertrophy and lesions of that tissue.