Hypothetical Protein Cpn0308 Is Localized in the Chlamydia pneumoniae Inclusion Membrane
- 1 January 2007
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 75 (1) , 497-503
- https://doi.org/10.1128/iai.00935-06
Abstract
The hypothetical protein encoded by Chlamydia pneumoniae open reading frame cpn0308 was detected in inclusion membranes of C. pneumoniae -infected cells using antibodies raised with Cpn0308 fusion proteins. The anti-Cpn0308 antibodies did not cross-react with IncA, a known C. pneumoniae inclusion membrane protein, although the anti-Cpn0308 antibody staining overlapped with the anti-IncA antibody labeling. The labeling of the inclusion membrane by the anti-Cpn0308 antibody was specifically blocked by the Cpn0308 but not IncA fusion proteins. The Cpn0308 antigen was detectable 24 h after infection and remained in the inclusion membrane throughout the infection course.Keywords
This publication has 32 references indexed in Scilit:
- Profiling of Human Antibody Responses toChlamydia trachomatisUrogenital Tract Infection Using Microplates Arrayed with 156 Chlamydial Fusion ProteinsInfection and Immunity, 2006
- Secretion of Cpn0796 from Chlamydia pneumoniae into the host cell cytoplasm by an autotransporter mechanismCellular Microbiology, 2005
- Tumor Necrosis Factor Alpha Plays a Role in the Acceleration of Atherosclerosis byChlamydia pneumoniaein MiceInfection and Immunity, 2005
- Chlamydia pneumoniae — an infectious risk factor for atherosclerosis?Nature Reviews Microbiology, 2004
- Chlamydia pneumoniaeSecretion of a Protease-Like Activity Factor for Degrading Host Cell Transcription Factors Is Required for Major Histocompatibility Complex Antigen ExpressionInfection and Immunity, 2002
- Identification of a Chlamydial Protease–Like Activity Factor Responsible for the Degradation of Host Transcription FactorsThe Journal of Experimental Medicine, 2001
- The atherogenic effects of chlamydia are dependent on serum cholesterol and specific to Chlamydia pneumoniaeJournal of Clinical Investigation, 1999
- Origins and functions of the chlamydial inclusionTrends in Microbiology, 1997
- Sphingolipids and glycoproteins are differentially trafficked to the Chlamydia trachomatis inclusion.The Journal of cell biology, 1996
- Cloning and characterization of a Chlamydia psittaci gene coding for a protein localized in the inclusion membrane of infected cellsMolecular Microbiology, 1995