Highly Diastereoselective and Enantioselective Synthesis of Enantiopure C2-Symmetrical Vicinal Diamines by Reductive Homocoupling of Chiral N-tert-Butanesulfinyl Imines
- 12 November 2004
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (25) , 4747-4750
- https://doi.org/10.1021/ol0479803
Abstract
[reaction: see text] An efficient and straightforward method for the preparation of highly enantiomerically enriched C2-symmetrical vicinal diamines by the reductive homocoupling of aromatic N-tert-butanesulfinyl imines in the presence of SmI2 and HMPA was developed. It gives access to a variety of enantiopure C2-symmetrical 1,2-diamines in a very mild and practical way.Keywords
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