Functional analysis of proteins involved in Plasmodium falciparum merozoite invasion of red blood cells
Open Access
- 26 June 2000
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 476 (1-2) , 84-88
- https://doi.org/10.1016/s0014-5793(00)01703-8
Abstract
Plasmodium falciparum causes the most lethal form of malaria in humans and is responsible for over two million deaths per year. The development of a vaccine against this parasite is an urgent priority and potential protein targets include those on the surface of the asexual merozoite stage, the form that invades the host erythrocyte. The development of methods to transfect P. falciparum has enabled the construction of gain‐of‐function and loss‐of‐function mutants and provided new strategies to analyse the role of parasite proteins. In this review, we describe the use of this technology to examine the role of merozoite antigens in erythrocyte invasion and to address their potential as vaccine candidates.Keywords
This publication has 48 references indexed in Scilit:
- Solution structure of an EGF module pair from the Plasmodium falciparum merozoite surface protein 1 1 1Edited by P. E. WrightJournal of Molecular Biology, 1999
- Chromosome 2 Sequence of the Human Malaria ParasitePlasmodium falciparumScience, 1998
- Clinical Immunity to Plasmodium falciparum Malaria Is Associated with Serum Antibodies to the 19-kDa C-Terminal Fragment of the Merozoite Surface Antigen, PfMSP-lThe Journal of Infectious Diseases, 1996
- Analysis of sequence diversity in the Plasmodium falciparum merozoite surface protein-1 (MSP-1)Molecular and Biochemical Parasitology, 1993
- Inhibitory monoclonal antibodies recognise epitopes adjacent to a proteolytic cleavage site on the RAP-1 protein of Plasmodium falciparumMolecular and Biochemical Parasitology, 1992
- A rhoptry antigen ofPlasmodium falciparumis protective inSaimirimonkeysParasitology, 1990
- Evidence for a switching mechanism in the invasion of erythrocytes by Plasmodium falciparum.Journal of Clinical Investigation, 1990
- Characterisation and sequence of a protective rhoptry antigen from Plasmodium falciparumMolecular and Biochemical Parasitology, 1990
- A rhoptry antigen of Plasmodium falciparum contains conserved and variable epitopes recognized by inhibitory monoclonal antibodiesMolecular and Biochemical Parasitology, 1986
- The three major antigens on the surface of Plasmodium falciparum merozoites are derived from a single high molecular weight precursor.The Journal of Experimental Medicine, 1984