EFFECT OF PREMEDICATION ON DRUG ABSORPTION AND GASTRIC EMPTYING
Open Access
- 1 December 1983
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 55 (12) , 1189-1193
- https://doi.org/10.1093/bja/55.12.1189
Abstract
The rate of paracetamol absorption after oral administration was used as a model of drug absorption and as an indirect measure of the rate of gastric emptying in 37 patients awaiting elective general surgery after different premedications. After saline (control) and diazepam, paracetamol absorption was normal but after morphine or nefopam, absorption was delayed markedly, presumably as a result of delayed gastric emptying. After naloxone there was a small but insignificant delay.Keywords
This publication has 5 references indexed in Scilit:
- Naloxone and morphine inhibit gastric emptying of solidsCanadian Journal of Physiology and Pharmacology, 1982
- In vitro biochemical effects of nefopam hydrochloride, a new analgesic agentBiochemical Pharmacology, 1981
- Gastric emptying after oesophagectomy as assessed by plasma paracetamol concentrations.Thorax, 1981
- Kinetics of acetaminophen absorption and gastric emptying in manClinical Pharmacology & Therapeutics, 1978
- SOME PHARMACOLOGICAL FACTORS INFLUENCING THE ABSORPTION OF DIAZEPAM FOLLOWING ORAL ADMINISTRATIONBritish Journal of Anaesthesia, 1976