Type A influenza (H2N2) viruses isolated in Leningrad in 1980

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Abstract
SUMMARY: In April-May 1980, two independent outbreaks of influenza-like illness occurred in Leningrad among children's-home children aged from 3 months to 2 years (of 68 children under observation, 50 became ill) and among boarding-school pupils aged 15–17 years (of 50 pupils under observation, 13 became ill).A total of five influenza A virus strains were derived from one clinically healthy and three affected children of the children's home. Similar viruses were obtained from one affected boarding-school pupil and from an infected woman aged 24 years (a sporadic case within a household). On the basis of laboratory findings, all these seven strains were identified as influenza A H2N2 subtype strains.Six of the affected children showed significant seroconversion only to H2 haemagglutinin from February to May 1980. Type A influenza H2N2 virus was isolated from three persons, including the sporadic case, who also showed significant seroconversion to H2 haemagglutinin. H2N2 influenza A virus was isolated on two occasions, at a 7-day interval, from the girl N. Ju.Laboratory findings obtained from the study of the viruses isolated using up-to-date immunological and molecular-biochemical techniques enable us to conclude the following. The A/Leningrad/80 isolates belong to H2N2 sero-subtype. The viruses isolated are similar but not identical to the A/Singapore/I/57 reference strain in details of polypeptide and gene composition.