Changes in Mitochondrial DNA as a Marker of Nucleoside Toxicity in HIV-Infected Patients
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Open Access
- 14 March 2002
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 346 (11) , 811-820
- https://doi.org/10.1056/nejmoa012035
Abstract
Nucleoside analogues can induce toxic effects on mitochondria by inhibiting the human DNA polymerase γ. The toxic effects can range from increased serum lactate levels to potentially fatal lactic acidosis. We studied changes in mitochondrial DNA relative to nuclear DNA in the peripheral-blood cells of patients with symptomatic, nucleoside-induced hyperlactatemia.Keywords
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