PREVIOUS DIET AND THE RÔLE OF THE KIDNEY IN THE METABOLISM OF THE EVISCERATED RAT

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Abstract
Nephrectomy largely eliminated the ability of previously fat-fed rats, after evisceration, to maintain a higher blood sugar level and to survive longer than similarly-treated carbohydrate-fed animals. The relatively small difference which remains may be due to blood acetone bodies present for a few hrs. after operation in the fat-fed group. The differences in metabolism in the non-nephrectomized eviscerated rats suggest that the metabolism of fat in the kidneys of these animals is affected by the fat content of the preceding diet. Thus, there was a significant increase in the concn. of fatty acids in the kidneys of the fat-fed rats during the 6-hr. period following evisceration; this did not occur in the carbohydrate-fed group. Renal metabolism of glucose, amino acids, and total N was apparently unaffected by previous diet.

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